K-RAS is a highly relevant oncogene that is mutated in approximately 90% of pancreatic
cancers and 20–25% of lung adenocarcinomas. The aim of this work was to develop a new …

Recent development has enabled synergistic drugs in treating a wide range of cancers.
Being highly context-dependent, however, identification of successful ones often requires …

Multicellular tumor spheroids have emerged as well-structured, three-dimensional culture
models that resemble and mimic the complexity of the dense and hypoxic cancer …

Lipid nanoparticles (LNPs) currently dominate the RNA delivery landscape; however their
limited diffusivity hampers targeted tissue dissemination, and, hence, their capacity for …

Polymer-drug conjugates have been actively developed as potential anticancer drug
delivery systems. In this study, we report the first polymer-anticancer drug conjugate with …

Glioblastoma (GBM) spheroids present as a promising alternative testing platform for in vivo
models of brain cancer, aiming at the 3Rs principle of animal use in pre-clinical trials …

Glioblastoma (GBM) aggressiveness is partly driven by the reactivation of signaling
pathways such as Sonic hedgehog (SHH) and the interaction with its microenvironment …

Background Photodynamic therapy (PDT), mainly as a combined therapy, can still be
considered a promising technology for targeted cancer treatment. Besides the several and …

HepG2 cells continue to be a valuable tool in early drug discovery and pharmaceutical
development. In the current study we develop a 3D in vitro liver model, using HepG2/C3A …

Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose)
polymerase inhibitor olaparib offer potential drug–drug synergy for the treatment of triple …