Each year, new drugs are introduced to the market, representing structures that have affinity
for biological targets implicated in human diseases and conditions. These new chemical …

Eye tracking has emerged as a reliable neuroscience tool indexing the eye movements'
correlates of impairments resulting from alcohol-use disorders, ranging from perceptive …

Background The main neurobiological theories of the development of addiction, including
tolerance, sensitization, incentive-sensitization, and allostasis, have not been tested in …

Attributes of alcohol sensitivity are present before alcohol use disorders (AUD s) develop,
they predict those adverse alcohol outcomes, are familial in nature, and many are heritable …

Background Individual differences in the subjective experience of the pharmacological
effects of alcohol have long been implicated in the likelihood that one will drink heavily and …

Rationale Preclinical studies report attenuated ethanol-induced conditioned taste aversion
(CTA) following chronic ethanol exposure, suggesting that tolerance develops to the …

Acute alcohol intoxication and alcohol use disorders are characterized by a wide range of
psychological and cerebral impairments, which have been widely explored using …

Background Koob's allostatic model of addiction emphasizes the transition from positive
reinforcement to negative reinforcement as dependence develops. This study seeks to …

Background Despite a rich literature on human laboratory paradigms of subjective response
(SR) to alcohol, craving for alcohol, and alcohol self‐administration, few studies have …

There is a strong association between cigarette smoking and alcohol use at the
epidemiological, behavioral, and molecular levels, and this co-use creates substantial …