Highlights●Why biofuels and bioproducts remain critical to society●What molecular
products can be made by biotechnology using available feedstocks●How new systems and …

Mechanisms of evolution and evolution of antibiotic resistance are both fundamental and
world health problems. Stress-induced mutagenesis defines mechanisms of mutagenesis …

Antibiotics can induce mutations that cause antibiotic resistance. Yet, despite their
importance, mechanisms of antibiotic-promoted mutagenesis remain elusive. We report that …

If biomanufacturing can become a sustainable route for producing chemicals, it will provide
a critical step in reducing greenhouse gas emissions to fight climate change. However …

The rise in fluorescence-based imaging techniques over the past 3 decades has improved
the ability of researchers to scrutinize live cell biology at increased spatial and temporal …

A common feature of bacterial, fungal and cancer cell populations upon treatment is the
presence of tolerant and persistent cells able to survive, and sometimes grow, even in the …

Mutation rates affect both a population's present fitness and its capacity to adapt to future
environmental changes. When the available genetic variability limits adaptation to …

Highlights•Phenotypic heterogeneity is an inevitable consequence of gene
expression.•Gene expression noise has functional consequences (eg survival …

Genetically identical cells frequently exhibit striking heterogeneity in various phenotypic
traits such as their morphology, growth rate, or gene expression. Such non-genetic diversity …

The efficiency of replication error repair is a critical factor governing the emergence of
mutations. However, it has so far been impossible to study this efficiency at the level of …