Genetic and epigenetic etiology underlying autism spectrum disorder
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized
by difficulties in social interaction, language development delays, repeated body …
by difficulties in social interaction, language development delays, repeated body …
[HTML][HTML] In vitro modeling of the neurobiological effects of glucocorticoids: A review
K Bassil, AC Krontira, T Leroy, AIH Escoto… - Neurobiology of …, 2023 - Elsevier
Hypothalamic-pituitary adrenal (HPA) axis dysregulation has long been implicated in stress-
related disorders such as major depression and post-traumatic stress disorder …
related disorders such as major depression and post-traumatic stress disorder …
Advanced Multi-Dimensional Cellular Models as Emerging Reality to Reproduce In Vitro the Human Body Complexity
A hot topic in biomedical science is the implementation of more predictive in vitro models of
human tissues to significantly improve the knowledge of physiological or pathological …
human tissues to significantly improve the knowledge of physiological or pathological …
Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through
Neurodegenerative diseases are adult-onset neurological conditions that are notoriously
difficult to model for drug discovery and development because most models are unable to …
difficult to model for drug discovery and development because most models are unable to …
Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs
C Brighi, F Salaris, A Soloperto, F Cordella… - Cell Death & …, 2021 - nature.com
Fragile X syndrome (FXS) is a neurodevelopmental disorder, characterized by intellectual
disability and sensory deficits, caused by epigenetic silencing of the FMR1 gene and …
disability and sensory deficits, caused by epigenetic silencing of the FMR1 gene and …
[HTML][HTML] Decellularized extracellular matrix-based 3D nanofibrous scaffolds functionalized with polydopamine-reduced graphene oxide for neural tissue engineering
DM da Silva, N Barroca, SC Pinto, Â Semitela… - Chemical Engineering …, 2023 - Elsevier
One of the exciting prospects of using decellularized extracellular matrices (ECM) lies in
their biochemical profile of preserved components, many of which are regeneration …
their biochemical profile of preserved components, many of which are regeneration …
Bilirubin-induced neurological damage: current and emerging iPSC-derived brain organoid models
AI Pranty, S Shumka, J Adjaye - Cells, 2022 - mdpi.com
Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades,
yet the molecular mechanisms at the core of this damage remain largely unknown …
yet the molecular mechanisms at the core of this damage remain largely unknown …
Stem cells: innovative therapeutic options for neurodegenerative diseases?
G Bonaventura, A Munafò, CM Bellanca, V La Cognata… - Cells, 2021 - mdpi.com
Neurodegenerative diseases are characterized by the progressive loss of structure and/or
function of both neurons and glial cells, leading to different degrees of pathology and loss of …
function of both neurons and glial cells, leading to different degrees of pathology and loss of …
[HTML][HTML] 3D models currently proposed to investigate human skin aging and explore preventive and reparative approaches: A descriptive review
F Lombardi, FR Augello, A Ciafarone, V Ciummo… - Biomolecules, 2024 - mdpi.com
Skin aging is influenced by intrinsic and extrinsic factors that progressively impair skin
functionality over time. Investigating the skin aging process requires thorough research …
functionality over time. Investigating the skin aging process requires thorough research …
Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies
S Santarelli, C Londero, A Soldano… - Frontiers in …, 2023 - frontiersin.org
Proteinopathies are a large group of neurodegenerative diseases caused by both genetic
and sporadic mutations in particular genes which can lead to alterations of the protein …
and sporadic mutations in particular genes which can lead to alterations of the protein …