The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′
untranslated regions (3′ UTRs) of target gene mRNAs represses translation, playing a …

Methadone is a synthetic, long-acting opioid with a single chiral center forming two
enantiomers,(R)-methadone and (S)-methadone, each having specific pharmacological …

Background Interindividual variability in methadone disposition remains unexplained, and
methadone accidental overdose in pain therapy is a significant public health problem …

Background Adequate opioid prescribing is critical for therapeutic success of pain
management. Despite the widespread use of opioids, optimized opioid therapy remains …

Background Genetic variability may influence methadone metabolism, dose requirements,
and risk of relapse. Objectives To determine whether the CYP2B6* 6 or ABCB1 (rs1045642) …

Chronic pain management represents a serious healthcare problem worldwide. Chronic
pain affects approximately 20% of the adult European population and is more frequent in …

Methadone is utilized for the treatment of individuals with opiate dependence. Methadone
undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including …

Methadone N‐demethylation in vitro is catalyzed by hepatic cytochrome P4502B6 (CYP2B6)
and CYP3A4, but clinical disposition is often attributed to CYP3A4. This investigation tested …

Translating pharmacogenetics to clinical practice has been particularly challenging in the
context of pain, due to the complexity of this multifaceted phenotype and the overall …

This manuscript reviews the CYP-mediated production of oxylipins and the current known
function of these diverse set of oxylipins with emphasis on the detoxification CYPs in families …