Chemotherapy is a well-known and effective treatment for different cancers; unfortunately, it
has not been as efficient in the eradication of all cancer cells as been expected. The …

Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …

The expanding spectrum of both established and candidate oncogenic driver mutations
identified in non-small-cell lung cancer (NSCLC), coupled with the increasing number of …

With the development of precision medicine, molecular targeted therapy has been widely
used in the field of cancer, especially in non-small-cell lung cancer (NSCLC). Epidermal …

Cross-talk between the tumor microenvironment (TME) and cancer cells plays an important
role in acquired drug resistance to epidermal growth factor receptor tyrosine kinase …

Cyclosporine A (CsA) is a cyclic undecapeptide with strong immunosuppressive potency.
Firstly marketed in the mid-1980s, CsA was widely used in transplantation and greatly …

Cyclosporine A (CsA) is a widely used immunosuppressive agent that greatly reduces the
rates of kidney-, heart-, and liver-transplant rejection. However, CsA nephrotoxicity is a …

Excessive activation of signal transducer and activator of transcription 3 (STAT3) signaling is
observed in a subset of many cancers, making activated STAT3 a highly promising potential …

Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is a
common feature in human non-small cell lung cancer (NSCLC). STAT3 plays an important …

Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-
associated inflammation contributes to tumor initiation and progression. However, it remains …