Huntington's disease is a progressive neurological disorder that starts insidiously with motor,
cognitive or psychiatric disturbance, and progresses through a distressing range of …

Histamine plays pleiotropic roles as a neurotransmitter in the physiology of brain function,
this includes the maintenance of wakefulness, appetite regulation and memory retrieval …

Objective To determine whether histamine cells are altered in human narcolepsy with
cataplexy and in animal models of this disease. Methods Immunohistochemistry for histidine …

Histamine and hypocretin neurons are localized to the hypothalamus, a brain area critical to
autonomic function and sleep. Narcolepsy type 1, also known as narcolepsy with cataplexy …

Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus,
from where they project to many brain areas. The histaminergic system is involved in basic …

Apathy is a highly prevalent symptom of dementia. Despite its association with faster
cognitive and functional decline, decreased quality of life and increased mortality, no …

Brain histamine is a neurotransmitter and regulates diverse physiological functions.
Previous studies have shown the involvement of histamine depletion in several neurological …

Microglia mediate neuroinflammation and regulate brain development and homeostasis.
Microglial abnormalities are implicated in a range of neuropsychiatric pathology, including …

Histamine, which is synthesized by histidine decarboxylase (HDC), does not only modulate
the immune system, but is also acting as a neurotransmitter. Histaminergic neurons project …

Brain histamine may affect a variety of different behavioral and physiological functions;
however, its role in promoting wakefulness has overshadowed its other important functions …