Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

Abstract This Review Article is focused on the action of the reactive oxygenated species in
inducing oxidative injury of the lipid membrane components, as well as on the ability of …

Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …

Biological tissues require oxygen to meet their energetic demands. However, the
consumption of oxygen also results in the generation of free radicals that may have …

Accumulating evidence shows that oxidative stress is involved in a wide variety of human
diseases: rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, cancers, etc. Here …

There is growing evidence that patients with Type 2 diabetes have an increased risk of
developing Parkinson's disease and share similar dysregulated pathways suggesting …

Parkinson's disease affects 5 million people worldwide, but the molecular mechanisms
underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis …

It is estimated that the prevalence rate of Alzheimer's disease (AD) will double by the year
2040. Although currently available treatments help with symptom management, they do not …