The Slit family is a family of secreted proteins that play important roles in various physiologic
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

Fusion of RET with different partner genes has been detected in papillary thyroid, lung,
colorectal, pancreatic, and breast cancer. Approval of selpercatinib for treatment of lung and …

One of the fundamental properties of a neuronal circuit is the map of its connections. The
cellular and developmental processes that allow for the growth of axons and dendrites …

Axon pathfinding is critical for nervous system development, and it is orchestrated by
molecular cues that activate receptors on the axonal growth cone. Robo family receptors …

Proper brain function requires high-precision neuronal expansion and wiring, processes
controlled by the transmembrane Roundabout (Robo) receptor family and their Slit ligands …

To investigate favorable single amino acid substitutions that improve antigen-antibody
interactions, alanine (Ala) mutagenesis scanning of the interfacial residues of a cancer …

Congenital anomalies of the kidney and urinary tract (CAKUT) represent the most common
cause of chronic kidney failure in children. Despite growing knowledge of the genetic …

The SLIT family (SLIT1-3) of highly conserved glycoproteins was originally identified as
ligands for the Roundabout (ROBO) family of single-pass transmembrane receptors, serving …

Abstract Human roundabout 1 (hRobo1) is an extracellular receptor glycoprotein that plays
important roles in angiogenesis, organ development, and tumor progression. Interaction …