Impact of low tacrolimus exposure and high tacrolimus intra-patient variability on the development of de novo anti-HLA donor-specific antibodies in kidney transplant …
A Mendoza Rojas, DA Hesselink… - Expert review of …, 2019 - Taylor & Francis
Introduction: De novo donor-specific antibodies (dn DSA) directed against HLA are a major
contributing factor to the chronic deterioration of renal allograft function. Several factors …
contributing factor to the chronic deterioration of renal allograft function. Several factors …
[HTML][HTML] Novel insights in the clinical management of hyperimmune patients before and after transplantation
V Grimaldi, M Pagano, G Moccia, C Maiello… - Current Research in …, 2023 - Elsevier
Despite improvements in anti-Human Leucocyte Antigens antibody detection, identification,
and characterization offer a better in peri-operative management techniques, antibodies …
and characterization offer a better in peri-operative management techniques, antibodies …
Impacts of high intra-and inter-individual variability in tacrolimus pharmacokinetics and fast tacrolimus metabolism on outcomes of solid organ transplant recipients
Tacrolimus is a first-line calcineurin inhibitor (CNI) and an integral part of the
immunosuppressive strategy in solid organ transplantation. Being a dose-critical drug …
immunosuppressive strategy in solid organ transplantation. Being a dose-critical drug …
Everolimus plus reduced calcineurin inhibitor prevents de novo anti-HLA antibodies and humoral rejection in kidney transplant recipients: 12-month results from the …
W Arns, A Philippe, V Ditt, IA Hauser… - Frontiers in …, 2023 - frontiersin.org
Background Studies prospectively monitoring de novo donor-specific antibodies (dnDSAs)
and their clinical impact are sparse. This substudy of ATHENA was initiated to evaluate the …
and their clinical impact are sparse. This substudy of ATHENA was initiated to evaluate the …
De novo donor-specific HLA antibodies reduce graft survival rates and increase the risk of kidney transplant rejection: a single-center retrospective study
W Liu, J Zhao, ZY Kang, YL Xiao, L Yang, C Liu… - Transplant …, 2021 - Elsevier
Background We investigated the impact of de novo donor-specific anti-human leukocyte
antigen antibodies (dnDSAs) on long-term death-censored graft survival and renal allograft …
antigen antibodies (dnDSAs) on long-term death-censored graft survival and renal allograft …
High tacrolimus intrapatient variability and subtherapeutic immunosuppression are associated with adverse kidney transplant outcomes
AM Rojas, DA Hesselink, NM van Besouw… - Therapeutic Drug …, 2022 - journals.lww.com
Background: Kidney transplant recipients with high intrapatient variability (IPV) in tacrolimus
(Tac) exposure experience more rejection and reduced graft survival. To understand the …
(Tac) exposure experience more rejection and reduced graft survival. To understand the …
[HTML][HTML] The Clinical Utility of Post-Transplant Monitoring of Donor-Specific Antibodies in Stable Renal Transplant Recipients: A Consensus Report With Guideline …
DAJ van den Broek, S Meziyerh… - Transplant …, 2023 - frontierspartnerships.org
Solid phase immunoassays improved the detection and determination of the antigen-
specificity of donor-specific antibodies (DSA) to human leukocyte antigens (HLA). The …
specificity of donor-specific antibodies (DSA) to human leukocyte antigens (HLA). The …
Association between PIRCHE‐II scores and de novo allosensitization after reduction of immunosuppression during SARS‐CoV‐2 infection in kidney transplant …
K Castrezana‐Lopez, R Malchow… - Transplant Infectious …, 2023 - Wiley Online Library
Background Before the availability of mRNA vaccines, many transplant centers chose to
significantly reduce maintenance immunosuppression in kidney transplant recipients (KTRs) …
significantly reduce maintenance immunosuppression in kidney transplant recipients (KTRs) …
[HTML][HTML] Associations of Perioperative Red Blood Cell Transfusion With Outcomes of Kidney Transplantation in Korea Over a 16-Year Period
Y Kim, B Kim, M Kang, HJ Nam, DH Ko… - Journal of Korean …, 2023 - ncbi.nlm.nih.gov
Background This study investigated the associations between transfusion of different types
of red blood cell (RBC) preparations and kidney allograft outcomes after kidney …
of red blood cell (RBC) preparations and kidney allograft outcomes after kidney …
[HTML][HTML] Successful pregnancy and follow-up after in vitro fertilization of a kidney transplant patient with systemic lupus erythematosus, primary biliary cholangitis, and …
T Gastañaga-Holguera, M Calvo… - JBRA Assisted …, 2021 - ncbi.nlm.nih.gov
This report describes the case of a female kidney transplant patient with systemic lupus
erythematosus, primary biliary cholangitis, and postsurgical hypothyroidism due to Grave's …
erythematosus, primary biliary cholangitis, and postsurgical hypothyroidism due to Grave's …