Bacterial infections, especially the refractory treatment of drug-resistant bacteria, are one of
the greatest threats to human health. During the past decades, biomedical nanomaterials …

Endolysins are bacteriophage-encoded enzymes that can specifically degrade the
peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development …

The prevalence of antimicrobial resistance (AMR) has been rising quickly in recent years.
AMR has emerged as a significant obstacle to the treatment of infectious diseases, and …

Antimicrobial peptides (AMPs) are short oligopeptides that can penetrate the bacterial inner
and outer membranes. Together with cell-penetrating peptides (CPPs), they are called …

We designed a library of 24 cyclic peptides containing arginine (R) and tryptophan (W)
residues in a sequential manner [R n W n](n= 2–7) to study the impact of the hydrophilic …

Trp is unique among the amino acids since it is involved in many different types of
noncovalent interactions such as electrostatic and hydrophobic ones, but also in π-π, π …

There has recently been great concern regarding antibiotics due to potential drug resistance
and the impact of antibiotics on the environment. Antimicrobial peptides are believed to have …

The rapid development of multidrug-resistant pathogens against conventional antibiotics is a
global public health problem. The irrational use of antibiotics has promoted therapeutic …

Highlights•[W 4 KR 5] and [W 4 KR 5]-meropenem covalent conjugate were
synthesized.•MICs were evaluated against non-resistant and multi-drug resistant …

We report the synthesis and antibacterial activities of a series of amphiphilic membrane-
active peptides composed, in part, of various nongenetically coded hydrophobic amino …