Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …

Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Background Past clinical trials of docosahexaenoic Acid (DHA) supplements for the
prevention of Alzheimer's disease (AD) dementia have used lower doses and have been …

Many prospective studies have shown that a diet enriched in omega-3 polyunsaturated fatty
acids (n-3 PUFAs) can improve cognitive function during normal aging and prevent the …

Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …

Previous data have linked omega-3 fatty acids with risk of dementia. We aimed to assess the
longitudinal relationships of omega-3 polyunsaturated fatty acid intake as well as blood …

The APOE gene alleles modify human aging and the response to the diet at many levels
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …

Lipid droplets (LDs) serve as energy rich reservoirs and have been associated with
apolipoprotein E (APOE) and neurodegeneration. The E4 allele of APOE (E4) is the …

The ApoE4 allele is the most well-studied genetic risk factor for Alzheimer's disease, a
condition that is increasing in prevalence and remains without a cure. Precision nutrition …

The prevalence of Alzheimer's disease (AD) continues to rise due to the increasing aging
population. Among the various genetic factors associated with AD, apolipoprotein E (ApoE) …