Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …

S‐adenosyl methionine (SAM) is a universal biological cofactor that is found in all branches
of life where it plays a critical role in the transfer of methyl groups to various biomolecules …

Protein methylation is a common posttranslational modification that mostly occurs on
arginine and lysine residues. Arginine methylation has been reported to regulate RNA …

Abstract Hypoxia-inducible factor-1α (HIF-1α) mediates hypoxic responses and regulates
gene expression involved in angiogenesis, invasion and metabolism. Among the various …

Histone-modifying enzymes can regulate DNA damage-induced apoptosis through
modulation of p53 function. Here, we show that, in p53-deficient tumor cells, Set9 and LSD1 …

The eight mammalian Cbx proteins are chromodomain-containing proteins involved in
regulation of heterochromatin, gene expression, and developmental programs. They are …

Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation,
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …

Nuclear factor κ-B (NF-κB)-regulated inflammatory genes, such as TNF-α (tumor necrosis
factor-α), play key roles in the pathogenesis of inflammatory diseases, including diabetes …

Sox2 is a key factor for maintaining embryonic stem cell (ESS) pluripotency, but little is
known about its posttranslational regulation. Here we present evidence that the precise level …

Estrogen receptor α (ER) is a ligand-dependent transcription factor. Upon binding estrogen,
ER recruits coactivator complexes with histone acetyltransferase or methyltransferase …