A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

Transcription factors such as KLF1, along with epigenetic modifiers, play crucial roles in
establishing the proper onset and progression of terminal differentiation events. Studies from …

The platelet and megakaryocyte cytoskeletons are essential for formation and function of
these cells. A dynamic, properly organised tubulin and actin cytoskeleton is critical for the …

The final stages of mammalian erythropoiesis involve enucleation, membrane and proteome
remodeling, and organelle clearance. Concomitantly, the erythroid membrane skeleton …

The formin protein mDia2 plays a critical role in a number of cellular processes through its
ability to promote nucleation and elongation of actin filaments. In erythroblasts, this includes …

HIGHLIGHTS•In vitro and in vivo rat models were established to monitor erythropoiesis
under steady-state and stress conditions.•Compared with that in mice, stress erythropoiesis …

Nuclear actin plays a critical role in mediating mesenchymal stem cell (MSC) fate
commitment. In marrow-derived MSCs, the principal diaphanous-related formin Diaph3 …

Bone marrow engraftment of the hematopoietic stem and progenitor cells (HSPCs) involves
homing to the vasculatures and lodgment to their niches. How HSPCs transmigrate from the …

mDia formin proteins regulate the dynamics and organization of the cytoskeleton through
their linear actin nucleation and polymerization activities. We previously showed that mDia1 …

Background Glioblastoma is one of the most aggressive primary brain tumors, with a poor
outcome despite multimodal treatment. Methylation of the MGMT promoter, which predicts …