Abstract Development of the central nervous system is coordinated by intercellular signalling
centres established within the neural tube. The isthmic organizer (IsO), located between the …

Forebrain development is directed by secreted signaling molecules known as morphogens,
and morphogen signaling defects often lead to failed midline induction and …

Abstract At embryonic day 8.5, the LIM-homeodomain factor Lmx1a is expressed throughout
the otic placode but becomes developmentally restricted to non-sensory epithelia of the ear …

Prospective midbrain and cerebellum formation are coordinated by FGF ligands produced
by the isthmic organizer. Previous studies have suggested that midbrain and cerebellum …

Cerebellar GABAergic interneurons and glia originate from progenitors that delaminate from
the ventricular neuroepithelium and proliferate in the prospective white matter. Even though …

How brain connectivity has evolved to integrate the mammalian-specific neocortex remains
largely unknown. Here, we address how dorsal thalamic axons, which constitute the main …

The roof plate is an organizing center in the dorsal CNS that controls specification and
differentiation of adjacent neurons through secretion of the BMP and WNT signaling …

Habenular nuclei play a key role in the control of motor and cognitive behavior, processing
emotion, motivation, and reward values in the brain. Thus, analysis of the molecular and …

LIM homeobox genes are one of the most important subfamilies of homeobox genes which
encode LIM-homeodomain (LIM-HD) proteins featuring two LIM domains in their amino …

The complex expression pattern of fibroblast growth factor 8 (Fgf8) and the cellular
responses dependent on concentration of its mRNA in vertebrates suggest that Fgf8 should …