This review is focused on the structural and physicochemical aspects of metal cation
coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G …

Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …

Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

We introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide RNA G-
quadruplex (rG4) profiling method that couples rG4-mediated reverse transcriptase stalling …

Abstract RNA G-quadruplex (RG4) structures are involved in multiple biological processes.
Recent genome-wide analyses of human mRNA transcriptome identified thousands of …

Background Guanine-rich sequences are able to form complex RNA structures termed RNA
G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed …

G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …

Liquid–liquid phase separation plays an important role in a variety of cellular processes,
including the formation of membrane-less organelles, the cytoskeleton, signalling …

Recent study shows that the prime editing system fusing the Cas9 nickase and reverse
transcriptase could perform all types of gene modifications, including base substitutions …

G-quadruplexes are non-canonical nucleic-acid structures that control transcription,
replication, and recombination in organisms. G-quadruplexes are present in eukaryotes …