Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

Neuroendocrine tumours (NET) of the gastrointestinal tract and the lung are a rare and
heterogeneous group of tumours. The molecular characterization and the clinical …

Pancreatic β cells are mostly post-mitotic, but it is unclear what locks them in this state.
Perturbations including uncontrolled hyperglycemia can drive β cells into more pliable states …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Objective Insulinomas and non-functional pancreatic neuroendocrine tumours (NF-
PanNETs) have distinctive clinical presentations but share similar pathological features …

Although diabetes results in part from a deficiency of normal pancreatic beta cells, inducing
human beta cells to regenerate is difficult. Reasoning that insulinomas hold the “genomic …

Simple Summary New treatments that utilize targeted therapeutic agents or invigorations of
the host immune system to destroy cancer cells are not effective against all cancers or …

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by
dysregulation of parathyroid hormone release. The large majority of PHPT cases are …

Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms, arising from
neuroendocrine cells that are dispersed throughout the body. Around 20% of NETs occur in …

Background Exposure to environmental endocrine disrupting chemicals (EDCs) may play an
important role in the epidemic of metabolic diseases. Epigenetic alterations may functionally …