Emerging roles of exosomal miRNAs in diabetes mellitus

X He, G Kuang, Y Wu, C Ou - Clinical and translational …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches

P Düsing, A Zietzer, PR Goody, MR Hosen… - Journal of molecular …, 2021 - Springer
Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney
disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor …

Medial vascular calcification revisited: review and perspectives

P Lanzer, M Boehm, V Sorribas, M Thiriet… - European heart …, 2014 - academic.oup.com
Vascular calcifications (VCs) are actively regulated biological processes associated with
crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or …

Novel biomarkers in the diagnosis of chronic kidney disease and the prediction of its outcome

J Rysz, A Gluba-Brzózka, B Franczyk… - International journal of …, 2017 - mdpi.com
In its early stages, symptoms of chronic kidney disease (CKD) are usually not apparent.
Significant reduction of the kidney function is the first obvious sign of disease. If diagnosed …

A current understanding of vascular calcification in CKD

NJ Paloian, CM Giachelli - American Journal of Physiology …, 2014 - journals.physiology.org
Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have
significant cardiovascular morbidity and mortality that is in part due to the development of …

Mechanisms of cardiovascular disorders in patients with chronic kidney disease: a process related to accelerated senescence

J Carracedo, M Alique, C Vida, G Bodega… - Frontiers in cell and …, 2020 - frontiersin.org
Cardiovascular diseases (CVDs), especially those involving a systemic inflammatory
process such as atherosclerosis, remain the leading cause of morbidity and mortality in …

[HTML][HTML] Potential role of ACE2-related microRNAs in COVID-19-associated nephropathy

A Widiasta, Y Sribudiani, H Nugrahapraja… - Non-coding RNA …, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible
for coronavirus disease (COVID-19), potentially have severe kidney adverse effects. This …

Roles and regulation of extracellular vesicles in cardiovascular mineral metabolism

MC Blaser, E Aikawa - Frontiers in cardiovascular medicine, 2018 - frontiersin.org
Cardiovascular calcification is a multifaceted disease that is a leading independent predictor
of cardiovascular morbidity and mortality. Recent studies have identified a calcification …

Initiation and propagation of vascular calcification is regulated by a concert of platelet-and smooth muscle cell-derived extracellular vesicles

LJ Schurgers, AC Akbulut, DM Kaczor… - Frontiers in …, 2018 - frontiersin.org
The ageing population continues to suffer from its primary killer, cardiovascular disease
(CVD). Despite recent advances in interventional medicinal and surgical therapies towards …

[HTML][HTML] Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways

NX Chen, KD O'Neill, SM Moe - Kidney international, 2018 - Elsevier
In patients with chronic kidney and end-stage renal diseases, the major risk factor for
progression of arterial calcification is the presence of existing (baseline) calcification. Here …