Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …

Foot-and-mouth disease (FMD) is the most economically important veterinary pathogen due
to its highly infectious nature, ability to cause persistent infections and long term effects on …

Foot-and-mouth disease virus (FMDV) was the first animal virus identified. Since then, FMDV
has become a model system in animal virology and a considerable amount of information on …

Foot-and-mouth disease virus (FMDV) is thought to evolve largely through genetic drift
driven by the inherently error-prone nature of its RNA polymerase. There is, however …

Background Picornaviruses are responsible for a wide range of mammalian diseases and,
in common with other RNA viruses, show considerable antigenic variation. Foot-and-mouth …

Escape of picornaviruses from neutralization by monoclonal antibodies is mediated by
substitutions of very few, defined amino acid residues of the capsid, generally located on the …

Passage of foot-and-mouth disease virus (FMDV) in cell culture in the presence of the
mutagenic base analog 5-fluorouracil or 5-azacytidine resulted in decreases of infectivity …

A large-scale vaccination experiment involving a total of 138 cattle was carried out to
evaluate the potential of synthetic peptides as vaccines against foot-and-mouth disease …

The molecular basis of Muller's ratchet has been investigated using the important animal
pathogen foot-and-mouth disease virus (FMDV). Clones from two FMDV populations were …

Cell surface molecules that can act as virus receptors may exert an important selective
pressure on RNA viral quasispecies. Large population passages of foot-and-mouth disease …