Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic
anemia, episodic vaso-occlusion, and progressive organ damage. Current management of …

Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell
disease. Symptomatic management and prevention of these events using the fetal …

Background and Aim: Previously, we found that short chain fatty acids (SCFA) inhibit LPS or
TNFα-induced endothelial inflammatory responses and excessive vascular cell adhesion …

Abstract Treatment of sickle cell disease (SCD) is hampered by incomplete understanding of
pathways linking hemolysis to vaso-occlusion. We investigated these pathways in …

For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical
features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin …

Background Sepsis-induced acute lung injury (ALI) is a clinical syndrome characterized by
the injury of alveolar epithelium and pulmonary endothelial cells. This study aimed to …

Erythrocytes regulate vascular function through the modulation of oxygen delivery and the
scavenging and generation of nitric oxide (NO). First, hemoglobin inside the red blood cell …

Persistence of human fetal hemoglobin (HbF, α2γ2) in adults lessens the severity of sickle
cell disease (SCD) and the β-thalassemias. Here, we show that the repressor BCL11A is …

Background—Hemolytic diseases are characterized by enhanced intravascular hemolysis
resulting in heme-catalyzed reactive oxygen species generation, which leads to endothelial …