Metalated isocyanides are highly versatile organometallics. Central to the reactivity of
metalated isocyanides is the presence of two orthogonally reactive carbons, a highly …

We describe a total synthesis of the rare isocyanoterpene natural product
isoneoamphilectane and two of its unnatural diastereomers. The significantly strained ring …

Oxazoles are rapidly assembled through a sequential deprotonation–condensation of
Asmic, anisylsulfanylmethylisocyanide, with esters followed by sulfanyl–lithium exchange …

A dearomatization-dislocation-coupling cascade rapidly transforms aromatic isocyanides
into highly functionalized cyclohexadienes. The facile cascade installs an exceptional …

The versatile isocyanide building block Asmic, anisylsulfanylmethylisocyanide, reacts with
aldehydes and ketones in a BF3· OEt2-mediated condensation to afford thioimidoyl …

Anisylsulfanylmethylisocyanide, Asmic, is a versatile building block whose alkylations
provide a range of substituted isocyanides. The anisylsulfanyl group plays a critical role in …

EtSiCl 3-treated silica gel,'C-2 silica,'proved exceptionally effective for purifying isocyanides
that are otherwise irreversibly adsorbed during silica gel chromatography. Purification of a …

A rare conjugate addition to isocyanoalkenes with ethyl cyanoacetate triggers an efficient
addition–cyclization–decarboxylation cascade. Using finely dispersed NaOH in THF as a …

A 3-neck, 500 mL round bottom flask (note 2), equipped with a magnetic stir bar (PTFE-
coated, cylindrical, 3 cm, Figure 1a) was charged with paraformaldehyde (17.7 g, 589 mmol …

A rapid, simple procedure is described for synthesizing trialkyl, dialkylaryl, and alkyldiaryl
sulfonium salts that features a selective extraction procedure to access analytically pure …