Aberrant activation of intracellular signalling pathways confers malignant properties on
cancer cells. Targeting intracellular signalling pathways has been a productive strategy for …

Since its discovery, the STAT3 transcription factor has been extensively studied for its
function as a transcriptional regulator and its role as a mediator of development, normal …

In June 2022, the FDA granted Accelerated Approval to the BRAF inhibitor dabrafenib in
combination with the MEK inhibitor trametinib for the treatment of adult and paediatric …

Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However,
during tumour progression and metastasis, cancerous epithelial cells must adapt to and …

Signal transduction activator of transcription (STAT) 3 is a member of the STAT protein family
which transduces intracellular and extracellular signals to the nucleus, controlling the …

Simple Summary Patients with advanced melanoma are often treated with v-raf murine
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …

The members of the Bcl-2 family are the central regulators of various cell death modalities.
Some of these proteins contribute to apoptosis, while others counteract this type of …

Dysregulation of the mitochondrial apoptotic pathway controlled by members of the Bcl-2
protein family plays a central role in cancer development and resistance to conventional …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated downstream of a broad range of receptors particularly interleukin-6 (IL-6) family …

Skin cancer has always been and remains the leader among all tumors in terms of
occurrence. One of the main factors responsible for skin cancer, natural and artificial UV …