Cyclin D1, an important regulator of cell cycle, carries out a central role in the pathogenesis
of cancer determining uncontrolled cellular proliferation. In normal cells, Cyclin D1 …

Unprecedented advances in our understanding of the pathobiology, prognostication, and
therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years …

The field of mantle cell lymphoma (MCL) has witnessed remarkable progress due to
relentless advances in molecular pathogenesis, prognostication, and newer treatments …

The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent
kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and …

The progression of cancers and neurodegenerative disorders is largely defined by a set of
molecular determinants that are either complementarily deregulated, or share remarkably …

Introduction: Despite unprecedented advances in the treatment of multiple myeloma (MM),
almost all patients develop a disease that is resistant to the five most commonly used and …

Blastoid and pleomorphic mantle cell lymphomas (MCLs) are variants of aggressive
histology MCL (AH-MCL). AH-MCL can arise de novo (AH-DN) or transform from prior …

Mangostin, which has the function of anti-inflammatory, antioxidant, and anticancer, etc, is
one of the main active ingredients of the hull of the mangosteen. The main objective of the …

Cyclin E, a regulatory subunit of cyclin-dependent kinase 2 (CDK2), is central to the initiation
of DNA replication at the G1/S checkpoint. Tight temporal control of cyclin E is essential to …

Cell proliferation requires metabolic reprogramming to accommodate biosynthesis of new
cell components, and similar alterations occur in cancer cells. However, the mechanisms …