[HTML][HTML] Amyloid beta: structure, biology and structure-based therapeutic development
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …
Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
J Nasica-Labouze, PH Nguyen, F Sterpone… - Chemical …, 2015 - ACS Publications
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
A partially folded structure of amyloid-beta (1–40) in an aqueous environment
S Vivekanandan, JR Brender, SY Lee… - Biochemical and …, 2011 - Elsevier
Aggregation of the Aβ1–40 peptide is linked to the development of extracellular plaques
characteristic of Alzheimer's disease. While previous studies commonly show the Aβ1–40 is …
characteristic of Alzheimer's disease. While previous studies commonly show the Aβ1–40 is …
[HTML][HTML] FTIR spectroscopic imaging of protein aggregation in living cells
LM Miller, MW Bourassa, RJ Smith - Biochimica et biophysica acta (BBA) …, 2013 - Elsevier
Protein misfolding and aggregation are the hallmark of a number of diseases including
Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …
Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …
Solution structure of the Alzheimer amyloid β‐peptide (1–42) in an apolar microenvironment: Similarity with a virus fusion domain
O Crescenzi, S Tomaselli, R Guerrini… - European journal of …, 2002 - Wiley Online Library
The major components of neuritic plaques found in Alzheimer disease (AD) are peptides
known as amyloid β‐peptides (Aβ), which derive from the proteolitic cleavage of the amyloid …
known as amyloid β‐peptides (Aβ), which derive from the proteolitic cleavage of the amyloid …
High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42 aggregates
T Watanabe-Nakayama, K Ono… - Proceedings of the …, 2016 - National Acad Sciences
Aggregation of amyloidogenic proteins into insoluble amyloid fibrils is implicated in various
neurodegenerative diseases. This process involves protein assembly into oligomeric …
neurodegenerative diseases. This process involves protein assembly into oligomeric …
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the misfolding and plaque-like accumulation of
a naturally occurring peptide in the brain called amyloid beta (Aβ). Recently, this process …
a naturally occurring peptide in the brain called amyloid beta (Aβ). Recently, this process …
Identification and characterization of key kinetic intermediates in amyloid β-protein fibrillogenesis
MD Kirkitadze, MM Condron, DB Teplow - Journal of molecular biology, 2001 - Elsevier
Amyloid β-protein (Aβ) assembly into toxic oligomeric and fibrillar structures is a seminal
event in Alzheimer's disease, therefore blocking this process could have significant …
event in Alzheimer's disease, therefore blocking this process could have significant …
Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease
Y Liu, D Zhuang, J Wang, H Huang, R Li, C Wu… - Analyst, 2022 - pubs.rsc.org
Nowadays, it is still quite challenging to achieve an early diagnosis of the Alzheimer disease
(AD) in clinics. The burgeoning near-infrared fluorescence (NIRF) imaging fulfills the …
(AD) in clinics. The burgeoning near-infrared fluorescence (NIRF) imaging fulfills the …
The chemistry of Alzheimer's disease
A Rauk - Chemical Society Reviews, 2009 - pubs.rsc.org
The chemistry of Alzheimer’s disease - Chemical Society Reviews (RSC Publishing) DOI:10.1039/B807980N
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B807980N …
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B807980N …