[HTML][HTML] Clonal hematopoiesis in children with predisposing conditions
Clonal hematopoiesis in children and young adults differs from that occuring in the older
adult population. A variety of stressors drive this phenomenon, sometimes independent of …
adult population. A variety of stressors drive this phenomenon, sometimes independent of …
Mathematical model of colorectal cancer initiation
Quantifying evolutionary dynamics of cancer initiation and progression can provide insights
into more effective strategies of early detection and treatment. Here we develop a …
into more effective strategies of early detection and treatment. Here we develop a …
[HTML][HTML] Mathematical modelling of clonal reduction therapeutic strategies in acute myeloid leukemia
M Brunetti, IA Iasenza, AL Jenner, NJM Raynal… - Leukemia Research, 2024 - Elsevier
Over the years, the overall survival of older patients diagnosed with acute myeloid leukemia
(AML) has not significantly increased. Although standard cytotoxic therapies that rapidly …
(AML) has not significantly increased. Although standard cytotoxic therapies that rapidly …
Predicting time to relapse in acute myeloid leukemia through stochastic modeling of minimal residual disease based on clonality data
Event‐free and overall survival remain poor for patients with acute myeloid leukemia.
Chemoresistant clones contributing to relapse arise from minimal residual disease (MRD) or …
Chemoresistant clones contributing to relapse arise from minimal residual disease (MRD) or …
Application of the moran model in estimating selection coefficient of mutated CSF3R clones in the evolution of severe congenital neutropenia to myeloid neoplasia
Bone marrow failure (BMF) syndromes, such as severe congenital neutropenia (SCN) are
leukemia predisposition syndromes. We focus here on the transition from SCN to pre …
leukemia predisposition syndromes. We focus here on the transition from SCN to pre …
[PDF][PDF] Integrated analysis of hub gene expression in multiple myeloma
Y Huang, J Huang, P Zhang, J Luo, P Cheng, L Miao… - J BUON, 2021 - jbuon.com
Purpose: To explore the expression and clinical significance of factors associated with
multiple myeloma (MM) and identify new diagnostic markers. Methods: Two gene …
multiple myeloma (MM) and identify new diagnostic markers. Methods: Two gene …
Modes of selection in tumors as reflected by two mathematical models and site frequency spectra
MK Kurpas, M Kimmel - Frontiers in ecology and evolution, 2022 - frontiersin.org
The tug-of-war model was developed in a series of papers of McFarland and co-authors to
account for existence of mutually counteracting rare advantageous driver mutations and …
account for existence of mutually counteracting rare advantageous driver mutations and …
Stochastic models of stem cells and their descendants under different criticality assumptions
NH Nguyen, M Kimmel - Stochastic Models, 2023 - Taylor & Francis
We study time continuous branching processes with exponentially distributed lifetimes, with
two types of cells that proliferate according to binary fission. A range of possible system …
two types of cells that proliferate according to binary fission. A range of possible system …
[PDF][PDF] Sara Biesiadny
M Kimmel - 2022 - repository.rice.edu
Clonal hematopoiesis (CH), or clonal hematopoiesis of indeterminate potential (CHIP) when
present in patients with no detectable hematologic malignancies [120], is a condition in …
present in patients with no detectable hematologic malignancies [120], is a condition in …