• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Hypertension in older adults is related to adverse cardiovascular outcomes, such as heart
failure, stroke, myocardial infarction, and death. The global burden of hypertension is …

Background The relationship between outpatient systolic and diastolic blood pressure and
cardiovascular outcomes remains unclear and has been complicated by recently revised …

This study compares the recommendations of the most recent American College of
Cardiology (ACC)/American Heart Association (AHA) and European Society of Cardiology …

Phytosterols (PSs), classified into plant sterols and stanols, are bioactive compounds found
in foods of plant origin. PSs have been proposed to exert a wide number of pharmacological …

The original KDIGO Clinical Practice Guideline for the Management of Blood Pressure in
Chronic Kidney Disease in the chronic kidney disease (CKD) population not receiving …

Background: Recent clinical guidelines support intensive blood pressure treatment targets.
However, observational data suggest that excessive diastolic blood pressure (DBP) …

Background: Arterial pressure is a complex signal that can be characterized by systolic,
mean, and diastolic components, along with pulse pressure (difference between systolic and …

Mendelian randomization (MR) is a powerful tool for causal inference with observational
genome-wide association study (GWAS) summary data. Compared to the more commonly …

BACKGROUND: Systolic blood pressure (SBP) lowering reduces major cardiovascular
disease (CVD) and all-cause mortality. However, the optimal target for SBP lowering …