Toward a foundation model of causal cell and tissue biology with a Perturbation Cell and Tissue Atlas
JE Rood, A Hupalowska, A Regev - Cell, 2024 - cell.com
Comprehensively charting the biologically causal circuits that govern the phenotypic space
of human cells has often been viewed as an insurmountable challenge. However, in the last …
of human cells has often been viewed as an insurmountable challenge. However, in the last …
Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development
Leveraging AAVs' versatile tropism and labeling capacity, we expanded the scale of in vivo
CRISPR screening with single-cell transcriptomic phenotyping across embryonic to adult …
CRISPR screening with single-cell transcriptomic phenotyping across embryonic to adult …
Transcriptome-wide characterization of genetic perturbations
Single cell CRISPR screens such as Perturb-seq enable transcriptomic profiling of genetic
perturbations at scale. However, the data produced by these screens are often noisy due to …
perturbations at scale. However, the data produced by these screens are often noisy due to …
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Organ function requires coordinated activities of thousands of genes in distinct, spatially
organized cell types. Understanding the basis of emergent tissue function requires …
organized cell types. Understanding the basis of emergent tissue function requires …
Beyond Traditional Bioremediation: The Potential of Engineered SynComs in Tackling Complex Environmental Pollutants
L Han - Genomics and Applied Biology, 2024 - bioscipublisher.com
Environmental pollution remains a critical global challenge, necessitating innovative and
effective remediation strategies. Traditional bioremediation methods, while eco-friendly and …
effective remediation strategies. Traditional bioremediation methods, while eco-friendly and …