The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment

SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

Effect of anesthesia on the developing brain: infant and fetus

DB Andropoulos - Fetal diagnosis and therapy, 2018 - karger.com
The potential for commonly used anesthetics and sedatives to cause neuroapoptosis and
other neurodegenerative changes in the developing mammalian brain has become evident …

Neuropsychological and behavioral outcomes after exposure of young children to procedures requiring general anesthesia: The MASK study

DO Warner, MJ Zaccariello, SK Katusic… - …, 2018 - pmc.ncbi.nlm.nih.gov
Background Few studies of how exposure of children to anesthesia may affect
neurodevelopment employ comprehensive neuropsychological assessments. This study …

Anesthesia and developing brains: unanswered questions and proposed paths forward

C Ing, DO Warner, LS Sun, RP Flick… - Obstetric Anesthesia …, 2022 - journals.lww.com
Optimizing surgical technique is an important part of improving outcomes in cesarean
delivery. It is unclear whether uterine exteriorization is associated with hemostasis benefits …

[HTML][HTML] Behavioral interventions for reducing head motion during MRI scans in children

DJ Greene, JM Koller, JM Hampton, V Wesevich… - Neuroimage, 2018 - Elsevier
A major limitation to structural and functional MRI (fMRI) scans is their susceptibility to head
motion artifacts. Even submillimeter movements can systematically distort functional …

[HTML][HTML] Prospectively assessed neurodevelopmental outcomes in studies of anaesthetic neurotoxicity in children: a systematic review and meta-analysis

C Ing, WM Jackson, MJ Zaccariello, TE Goldberg… - British journal of …, 2021 - Elsevier
Background Whether exposure to a single general anaesthetic (GA) in early childhood
causes long-term neurodevelopmental problems remains unclear. Methods …

Dexmedetomidine-mediated neuroprotection against sevoflurane-induced neurotoxicity extends to several brain regions in neonatal rats

JF Perez-Zoghbi, W Zhu, MR Grafe… - BJA: British Journal of …, 2017 - academic.oup.com
Background. Exposure of infant animals to clinically used anaesthetics is associated with
acute structural brain abnormalities and development functional alterations. The α2 …

General anesthesia in children and long-term neurodevelopmental deficits: A systematic review

A Xiao, Y Feng, S Yu, C Xu, J Chen, T Wang… - Frontiers in molecular …, 2022 - frontiersin.org
Background Millions of children experienced surgery procedures requiring general
anesthesia (GA). Any potential neurodevelopmental risks of pediatric anesthesia can be a …

Exposure of developing brain to general anesthesia: what is the animal evidence?

V Jevtovic-Todorovic - Anesthesiology, 2018 - pmc.ncbi.nlm.nih.gov
Over the past 15 years we have been witness to numerous research reports bringing an
uncomfortable concern that very young mammalian brain could be susceptible to …

The impact of general anesthesia on child development and school performance: a population‐based study

FJ Schneuer, JP Bentley, AJ Davidson… - Pediatric …, 2018 - Wiley Online Library
Background There has been considerable interest in the possible adverse neurocognitive
effects of exposure to general anesthesia and surgery in early childhood. Aims The aim of …