The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment
SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …
experience and is common in the elderly and patients with preexisting neurocognitive …
Effect of anesthesia on the developing brain: infant and fetus
DB Andropoulos - Fetal diagnosis and therapy, 2018 - karger.com
The potential for commonly used anesthetics and sedatives to cause neuroapoptosis and
other neurodegenerative changes in the developing mammalian brain has become evident …
other neurodegenerative changes in the developing mammalian brain has become evident …
Neuropsychological and behavioral outcomes after exposure of young children to procedures requiring general anesthesia: The MASK study
DO Warner, MJ Zaccariello, SK Katusic… - …, 2018 - pmc.ncbi.nlm.nih.gov
Background Few studies of how exposure of children to anesthesia may affect
neurodevelopment employ comprehensive neuropsychological assessments. This study …
neurodevelopment employ comprehensive neuropsychological assessments. This study …
Anesthesia and developing brains: unanswered questions and proposed paths forward
C Ing, DO Warner, LS Sun, RP Flick… - Obstetric Anesthesia …, 2022 - journals.lww.com
Optimizing surgical technique is an important part of improving outcomes in cesarean
delivery. It is unclear whether uterine exteriorization is associated with hemostasis benefits …
delivery. It is unclear whether uterine exteriorization is associated with hemostasis benefits …
[HTML][HTML] Behavioral interventions for reducing head motion during MRI scans in children
A major limitation to structural and functional MRI (fMRI) scans is their susceptibility to head
motion artifacts. Even submillimeter movements can systematically distort functional …
motion artifacts. Even submillimeter movements can systematically distort functional …
[HTML][HTML] Prospectively assessed neurodevelopmental outcomes in studies of anaesthetic neurotoxicity in children: a systematic review and meta-analysis
C Ing, WM Jackson, MJ Zaccariello, TE Goldberg… - British journal of …, 2021 - Elsevier
Background Whether exposure to a single general anaesthetic (GA) in early childhood
causes long-term neurodevelopmental problems remains unclear. Methods …
causes long-term neurodevelopmental problems remains unclear. Methods …
Dexmedetomidine-mediated neuroprotection against sevoflurane-induced neurotoxicity extends to several brain regions in neonatal rats
JF Perez-Zoghbi, W Zhu, MR Grafe… - BJA: British Journal of …, 2017 - academic.oup.com
Background. Exposure of infant animals to clinically used anaesthetics is associated with
acute structural brain abnormalities and development functional alterations. The α2 …
acute structural brain abnormalities and development functional alterations. The α2 …
General anesthesia in children and long-term neurodevelopmental deficits: A systematic review
A Xiao, Y Feng, S Yu, C Xu, J Chen, T Wang… - Frontiers in molecular …, 2022 - frontiersin.org
Background Millions of children experienced surgery procedures requiring general
anesthesia (GA). Any potential neurodevelopmental risks of pediatric anesthesia can be a …
anesthesia (GA). Any potential neurodevelopmental risks of pediatric anesthesia can be a …
Exposure of developing brain to general anesthesia: what is the animal evidence?
V Jevtovic-Todorovic - Anesthesiology, 2018 - pmc.ncbi.nlm.nih.gov
Over the past 15 years we have been witness to numerous research reports bringing an
uncomfortable concern that very young mammalian brain could be susceptible to …
uncomfortable concern that very young mammalian brain could be susceptible to …
The impact of general anesthesia on child development and school performance: a population‐based study
Background There has been considerable interest in the possible adverse neurocognitive
effects of exposure to general anesthesia and surgery in early childhood. Aims The aim of …
effects of exposure to general anesthesia and surgery in early childhood. Aims The aim of …