Malaria: biology and disease
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …
cause of death and disease across many tropical and subtropical countries. Over the last …
Invasion of red blood cells by malaria parasites
The malaria parasite is the most important member of the Apicomplexa, a large and highly
successful phylum of intracellular parasites. Invasion of host cells allows apicomplexan …
successful phylum of intracellular parasites. Invasion of host cells allows apicomplexan …
Structure-based design of a strain transcending AMA1-RON2L malaria vaccine
Abstract Apical membrane antigen 1 (AMA1) is a key malaria vaccine candidate and target
of neutralizing antibodies. AMA1 binds to a loop in rhoptry neck protein 2 (RON2L) to form …
of neutralizing antibodies. AMA1 binds to a loop in rhoptry neck protein 2 (RON2L) to form …
Protection against a malaria challenge by sporozoite inoculation
M Roestenberg, M McCall, J Hopman… - … England Journal of …, 2009 - Mass Medical Soc
Background An effective vaccine for malaria is urgently needed. Naturally acquired immunity
to malaria develops slowly, and induction of protection in humans can be achieved …
to malaria develops slowly, and induction of protection in humans can be achieved …
The silent path to thousands of merozoites: the Plasmodium liver stage
Plasmodium sporozoites are deposited in the skin of their vertebrate hosts through the bite
of an infected female Anopheles mosquito. Most of these parasites find a blood vessel and …
of an infected female Anopheles mosquito. Most of these parasites find a blood vessel and …
The moving junction of apicomplexan parasites: a key structure for invasion
S Besteiro, JF Dubremetz, M Lebrun - Cellular microbiology, 2011 - Wiley Online Library
Most Apicomplexa are obligate intracellular parasites and many are important pathogens of
human and domestic animals. For a successful cell invasion, they rely on their own motility …
human and domestic animals. For a successful cell invasion, they rely on their own motility …
Recent clinical experience with vaccines using MPL-and QS-21-containing adjuvant systems
N Garcon, M Van Mechelen - Expert review of vaccines, 2011 - Taylor & Francis
The immunostimulants 3-O-desacyl-4'-monophosphoryl lipid A (MPL) and the saponin QS-
21 are part of licensed or candidate vaccines. MPL and QS-21 directly affect the innate …
21 are part of licensed or candidate vaccines. MPL and QS-21 directly affect the innate …
Immune effector mechanisms in malaria
K Marsh, S Kinyanjui - Parasite immunology, 2006 - Wiley Online Library
That humans in endemic areas become immune to malaria offers encouragement to the
idea of developing protective vaccines. However natural immunity is relatively inefficient …
idea of developing protective vaccines. However natural immunity is relatively inefficient …
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax
The Plasmodium liver stage is an attractive target for the development of antimalarial drugs
and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a …
and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a …