Effect of fluoride on cytotoxicity involved in mitochondrial dysfunction: a review of mechanism

M Wei, Y Ye, MM Ali, Y Chamba, J Tang… - Frontiers in veterinary …, 2022 - frontiersin.org
Fluoride is commonly found in the soil and water environment and may act as chronic
poison. A large amount of fluoride deposition causes serious harm to the ecological …

Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches

AH Nagendra, B Bose, S Shenoy P - Molecular Biology Reports, 2021 - Springer
Fluoride is a natural element essential in minute quantities in human's to maintain dental
and skeletal health. However, the disease fluorosis manifests itself due to excessive fluoride …

[HTML][HTML] Fluoride exposure during pregnancy and lactation triggers oxidative stress and molecular changes in hippocampus of offspring rats

MKM Ferreira, WAB Aragão, LO Bittencourt… - Ecotoxicology and …, 2021 - Elsevier
Long-term exposure to high concentrations of fluoride (F) can damage mineralized and soft
tissues such as bones, liver, kidney, intestine, and nervous system of adult rats. The high …

Fluoride induced neurobehavioral impairments in experimental animals: a brief review

H Ottappilakkil, S Babu, S Balasubramanian… - … Trace Element Research, 2023 - Springer
Fluoride is one of the major toxicants in the environment and is often found in drinking water
at higher concentrations. Living organisms including humans exposed to high fluoride levels …

Effects of fluoride exposure on mitochondrial function: energy metabolism, dynamics, biogenesis and mitophagy

SH Avila-Rojas, OE Aparicio-Trejo… - Environmental …, 2022 - Elsevier
Fluoride is ubiquitous in the environment. Furthermore, drinking water represents the main
source of exposure to fluoride for humans. Interestingly, low fluoride concentrations have …

[HTML][HTML] F-53B mediated ROS affects uterine development in rats during puberty by inducing apoptosis

P Nie, Y Lan, T You, T Jia, H Xu - Ecotoxicology and Environmental Safety, 2024 - Elsevier
Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as pollutants, can cause palpable
environmental and health impacts around the world, as endocrine disruptors, can disrupt …

Effects of fluoride long-term exposure over the cerebellum: global proteomic profile, oxidative biochemistry, cell density, and motor behavior evaluation

GO Lopes, MK Martins Ferreira, L Davis… - International journal of …, 2020 - mdpi.com
Although the literature does not provide evidence of health risks from exposure to fluoride
(F) in therapeutic doses, questions remain about the effects of long-term and high-dose use …

[HTML][HTML] Nrf2/PINK1-mediated mitophagy induction alleviates sodium fluoride-induced hepatic injury by improving mitochondrial function, oxidative stress, and …

C Song, A Zhang, M Zhang, Y Song, H Huangfu… - Ecotoxicology and …, 2023 - Elsevier
Mitophagy has distinct functions, which can lead to either protection or damage of tissues.
Though current evidence indicated that NaF triggers mitophagy, the role and regulation of …

[HTML][HTML] Integrative transcriptome and metabolome analysis of fluoride exposure induced developmental neurotoxicity in mouse brain

X Zhu, S Zhang, X Liu, H Li, X Zhu, J Zhang… - Ecotoxicology and …, 2024 - Elsevier
Fluoride could cause developmental neurotoxicity and significantly affect the intelligence
quotient (IQ) of children. However, the systematic mechanism of neuronal damage caused …

[HTML][HTML] Metabolic effect of low fluoride levels in the islets of NOD mice: integrative morphological, immunohistochemical, and proteomic analyses

JS Trevizol, A Dionizio, AQ Delgado… - Journal of Applied Oral …, 2023 - SciELO Brasil
Fluoride (F) has been widely used to control dental caries, and studies suggest beneficial
effects against diabetes when a low dose of F is added to the drinking water (10 mgF/L) …