Stress induced by accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a
classic feature of secretory cells and is observed in many tissues in human diseases …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

The membrane of the endoplasmic reticulum (ER) of a cell forms contacts directly with
mitochondria whereby the contact is referred to as the m itochondrion-a ssociated ER m …

Wolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent
diabetes mellitus, caused by nonautoimmune loss of β cells, and neurological dysfunctions …

Alzheimer's disease (AD) is an incurable neurodegenerative disorder clinically
characterized by progressive cognitive impairment. A prominent pathologic hallmark in the …

Biological studies of bipolar disorder initially focused on the mechanism of action for
antidepressants and antipsychotic drugs, and the roles of monoamines (eg, serotonin …

In this review, all papers relevant to the molecular genetics of bipolar disorder published
from 2004 to the present (mid 2006) are reviewed, and major results on depression are …

Although glucose uniquely stimulates proinsulin biosynthesis in β cells, surprisingly little is
known of the underlying mechanism (s). Here, we demonstrate that glucose activates the …

Selective neuronal vulnerability to protein aggregation is found in many neurodegenerative
diseases including Alzheimer's disease (AD). Understanding the molecular origins of this …

The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell
survival under endoplasmic reticulum (ER) stress conditions. X-box-binding protein-1 (XBP …