Mutation or abnormal expression of protein tyrosine kinases (PTKs) is one of the main
causes of cancer. Fibroblast growth factor receptors (FGFRs) are a subfamily of tyrosine …

Single-atom catalysts (SACs) have generated excitement for their potential to downsize
metal particles to the atomic limit with engineerable local environments and improved …

Pyrazolylaminoquinazoline is obtained from synthetic AZD4547 and can inhibit kinase
activity in recombinant fibroblast growth factor receptor (FGFR) in vitro. The objective of this …

Introduction: FGFR1 is a well known molecular target for anticancer therapy. Many studies
have proved that the regulation of FGFR1 activity is a promising therapeutic approach to …

Dysregulation of the fibroblast growth factor receptor 1 (FGFR1) signaling has prompted
efforts to develop therapeutic agents, which is a carcinogenic driver of many cancers …

The recent FDA-approval of lenacapavir (LEN, GS-6207) and the subsequent discovery of
GSK878 strongly validate HIV-1 capsid protein (CA) as a target for antiviral development …

The heterocyclization of gem-dichlorocyclopropanes upon treatment with nitronium triflate in
organic nitriles was studied and the influence of the medium on the reaction pathway was …

Fibroblast growth factor receptor 1 (FGFR1) plays an important role in tumorigenesis,
suggesting that inhibitors of this protein kinase may become important compounds for the …

The synthetic covalent modification of biomolecules has provided remarkable advances in
our understanding of cellular phenomena and therapeutic development. Given the …

Herein we present an investigation into the scope and mechanism for the synthesis of
cyclopentyl and heterocyclic fused pyridones from the corresponding enyne amides. In the …