For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Sepsis is a systemic inflammatory response induced by an infection, leading to organ
dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were …

Sepsis—which is a severe life-threatening infection with organ dysfunction—initiates a
complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be …

Failures of highly touted trials have caused experts to call for re-evaluation of the current
approach toward sepsis. New research has revealed key pathogenic mechanisms; autopsy …

Background Acute respiratory distress syndrome (ARDS) is a life‐threatening condition
caused by direct or indirect injury to the lungs. Despite improvements in clinical …

The acute respiratory distress syndrome is a common, devastating clinical syndrome of
acute lung injury that affects both medical and surgical patients. Since the last review of this …

Sepsis is the leading cause of death in critically ill patients in the United States. Yet the
individual host response to septicemia is variable, depending on the patient's immune …

Melioidosis, caused by the gram-negative saprophyte Burkholderia pseudomallei, is a
disease of public health importance in southeast Asia and northern Australia that is …

Sepsis remains the leading cause of death in most intensive care units. Advances in
understanding the immune response to sepsis provide the opportunity to develop more …