Biosynthesis and synthetic biology of psychoactive natural products

CS Jamieson, J Misa, Y Tang… - Chemical Society Reviews, 2021 - pubs.rsc.org
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

Dark classics in chemical neuroscience: mescaline

BK Cassels, P Sáez-Briones - ACS chemical neuroscience, 2018 - ACS Publications
Archeological studies in the United States, Mexico, and Peru suggest that mescaline, as a
cactus constituent, has been used for more than 6000 years. Although it is a widespread …

Relaxation of tyrosine pathway regulation underlies the evolution of betalain pigmentation in Caryophyllales

S Lopez‐Nieves, Y Yang, A Timoneda… - New …, 2018 - Wiley Online Library
Diverse natural products are synthesized in plants by specialized metabolic enzymes, which
are often lineage‐specific and derived from gene duplication followed by functional …

Elucidation of the mescaline biosynthetic pathway in peyote (Lophophora williamsii)

JL Watkins, Q Li, S Yeaman, PJ Facchini - The Plant Journal, 2023 - Wiley Online Library
Peyote (Lophophora williamsii) is an entheogenic and medicinal cactus native to the
Chihuahuan desert. The psychoactive and hallucinogenic properties of peyote are …

An overview on the hallucinogenic peyote and its alkaloid mescaline: The importance of context, ceremony and culture

M Doesburg-van Kleffens, AM Zimmermann-Klemd… - Molecules, 2023 - mdpi.com
Peyote (Lophophora williamsii) is a cactus that contains various biologically active alkaloids—
such as pellotine, anhalonidine, hordenine and mescaline. Here, mescaline induces the …

Emerging model systems for functional genomics analysis of Crassulacean acid metabolism

J Hartwell, LV Dever, SF Boxall - Current Opinion in Plant Biology, 2016 - Elsevier
Highlights•Efforts are now underway to decipher the genetic blueprint for CAM.•Several
CAM genomes and transcriptomes have recently been published.•Kalanchoë has been …

The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

P Berman, LA de Haro, AR Cavaco, S Panda, Y Dong… - Molecular Plant, 2024 - cell.com
Mescaline, among the earliest identified natural hallucinogens, holds great potential in
psychotherapy treatment. Nonetheless, despite the existence of a postulated biosynthetic …

Transcriptomics insights into the genetic regulation of root apical meristem exhaustion and determinate primary root growth in Pachycereus pringlei (Cactaceae)

G Rodriguez-Alonso, M Matvienko, ML López-Valle… - Scientific Reports, 2018 - nature.com
Many Cactaceae species exhibit determinate growth of the primary root as a consequence
of root apical meristem (RAM) exhaustion. The genetic regulation of this growth pattern is …

The Alkaloids from Lophophora diffusa and Other “False Peyotes”

CB Chan, CBM Poulie, SS Wismann… - Journal of Natural …, 2021 - ACS Publications
Commonly, false peyote refers to Lophophora diffusa. However, several other unrelated
cacti go by this colloquial name. They either resemble “true” peyote, Lophophora williamsii …

L-DOPA and dopamine in plant metabolism

R Marchiosi, AR Soares, J Abrahão… - … in plant signaling and …, 2020 - Springer
Nonprotein amino acids are widely distributed in the plants. They constitute a numerous
group of secondary metabolites and represent a relevant reservoir of nitrogen and carbon …