Humanized mice as a valuable pre-clinical model for cancer immunotherapy research
MM Cogels, R Rouas, GE Ghanem, P Martinive… - Frontiers in …, 2021 - frontiersin.org
Immunotherapy with checkpoint inhibitors opened new horizons in cancer treatment. Clinical
trials for novel immunotherapies or unexplored combination regimens either need years of …
trials for novel immunotherapies or unexplored combination regimens either need years of …
Purification and functional characterization of novel human skeletal stem cell lineages
Human skeletal stem cells (hSSCs) hold tremendous therapeutic potential for developing
new clinical strategies to effectively combat congenital and age-related musculoskeletal …
new clinical strategies to effectively combat congenital and age-related musculoskeletal …
Cancer cell CD44 mediates macrophage/monocyte-driven regulation of head and neck cancer stem cells
Tumor-associated macrophages (TAM) in the tumor microenvironment (TME) cooperate with
cancer stem cells (CSC) to maintain stemness. We recently identified cluster of …
cancer stem cells (CSC) to maintain stemness. We recently identified cluster of …
Building the next generation of humanized hemato-lymphoid system mice
T Martinov, KM McKenna, WH Tan, EJ Collins… - Frontiers in …, 2021 - frontiersin.org
Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …
Mouse tumor-bearing models as preclinical study platforms for oral squamous cell carcinoma
Preclinical animal models of oral squamous cell carcinoma (OSCC) have been extensively
studied in recent years. Investigating the pathogenesis and potential therapeutic strategies …
studied in recent years. Investigating the pathogenesis and potential therapeutic strategies …
Mouse models for immuno-oncology
M Bosenberg, ET Liu, IY Chun, K Palucka - Trends in Cancer, 2023 - cell.com
Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our
knowledge of in vivo mechanisms underlying treatment response as well as treatment …
knowledge of in vivo mechanisms underlying treatment response as well as treatment …
Generation of orthotopic patient-derived xenografts in humanized mice for evaluation of emerging targeted therapies and immunotherapy combinations for melanoma
Simple Summary Patient-derived xenografts (PDX) are valuable models in preclinical
oncology drug development. However, they are not well suited for testing immune-based …
oncology drug development. However, they are not well suited for testing immune-based …
Mouse models for immune checkpoint blockade therapeutic research in oral cancer
WC Chiu, DL Ou, CT Tan - International Journal of Molecular Sciences, 2022 - mdpi.com
The most prevalent oral cancer globally is oral squamous cell carcinoma (OSCC). The
invasion of adjacent bones and the metastasis to regional lymph nodes often lead to poor …
invasion of adjacent bones and the metastasis to regional lymph nodes often lead to poor …
MSCs can be a double-edged sword in tumorigenesis
L Zhang, J Xiang, F Zhang, L Liu, C Hu - Frontiers in Oncology, 2022 - frontiersin.org
Mesenchymal stem cells (MSCs) have been used to treat various diseases including
Alzheimer's disease and cancer. In particular, the immunomodulatory function of MSCs …
Alzheimer's disease and cancer. In particular, the immunomodulatory function of MSCs …
Identity matters: cancer stem cells and tumour plasticity in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) represents frequent yet aggressive
tumours that encompass complex ecosystems of stromal and neoplastic components …
tumours that encompass complex ecosystems of stromal and neoplastic components …