Artificial intelligence (AI) coupled with promising machine learning (ML) techniques well
known from computer science is broadly affecting many aspects of various fields including …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …

A major drawback of single-cell ATAC-seq (scATAC-seq) is its sparsity, ie, open chromatin
regions with no reads due to loss of DNA material during the scATAC-seq protocol. Here, we …

Single-cell assay for transposase-accessible chromatin using sequencing (scATAC) shows
great promise for studying cellular heterogeneity in epigenetic landscapes, but there remain …

We review the current applications of artificial intelligence (AI) in functional genomics. The
recent explosion of AI follows the remarkable achievements made possible by “deep …

Abstract Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq)
accurately depicts the chromatin regulatory state and altered mechanisms guiding gene …

Abstract The N 6-methyladenosine (m6A) modification is deposited to nascent transcripts on
chromatin, but its site-specificity mechanism is mostly unknown. Here we model the m6A …

Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …

Single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) is
being increasingly used to study gene regulation. However, major analytical gaps limit its …

Single-cell ATAC sequencing (scATAC-seq) is a powerful and increasingly popular
technique to explore the regulatory landscape of heterogeneous cellular populations …