The effect of the pineal indole hormone melatonin on the life span of mice, rats and fruit flies
has been studied using various approaches. It has been observed that in female CBA, SHR …

Melatonin is a natural compound synthesized by a variety of organs. It has been shown to
function as a cell-protective agent. Since 1994, when the first paper was published …

Oxidative stress in conjunction with glutathione depletion has been linked with various acute
and chronic degenerative disorders, yet the molecular mechanisms have remained unclear …

Acute ocular hypertension (AOH) is the most important characteristic of acute glaucoma,
which can lead to retinal ganglion cell (RGC) death and permanent vision loss. So far …

Melatonin, the secretory product of the pineal gland, is known to be neuroprotective in
cerebral ischemia, which is so far mostly attributed to its antioxidant properties. Here we …

Ambivalent effects of interleukin-6 on the pathogenesis of ischaemic stroke have been
reported. However, to date, the long-term actions of interleukin-6 after stroke have not been …

Several lines of clinical and experimental evidence suggest an important role of the
reninangiotensin system in ischemic brain injury although the cellular regulation of the …

Focal cerebral ischemia activates the nuclear protein poly (ADP-ribose) polymerase (PARP)
by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or …

Melatonin is an indoleamine with potent multifunctional biological and pharmacological
effects, both receptor dependent and receptor-independent effects, including antioxidant …

After mild ischemic insults, many neurons undergo delayed neuronal death. Aberrant
activation of the cell cycle machinery is thought to contribute to apoptosis in various …