The pharmacokinetics and the pharmacodynamics of cannabinoids

CJ Lucas, P Galettis, J Schneider - British journal of clinical …, 2018 - Wiley Online Library
There is increasing interest in the use of cannabinoids for disease and symptom
management, but limited information available regarding their pharmacokinetics and …

Review of delta‐8‐tetrahydrocannabinol (Δ8‐THC): Comparative pharmacology with Δ9‐THC

M Tagen, LE Klumpers - British journal of pharmacology, 2022 - Wiley Online Library
The use of the intoxicating cannabinoid delta‐8‐tetrahydrocannabinol (Δ8‐THC) has grown
rapidly over the last several years. There have been dozens of Δ8‐THC studies dating back …

[HTML][HTML] Molecular targets of cannabidiol in neurological disorders

CI Bih, T Chen, AVW Nunn, M Bazelot, M Dallas… - …, 2015 - Elsevier
Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use.
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …

Consensus recommendations on dosing and administration of medical cannabis to treat chronic pain: results of a modified Delphi process

A Bhaskar, A Bell, M Boivin, W Briques… - Journal of cannabis …, 2021 - Springer
Background Globally, medical cannabis legalization has increased in recent years and
medical cannabis is commonly used to treat chronic pain. However, there are few …

Human metabolites of cannabidiol: a review on their formation, biological activity, and relevance in therapy

I Ujváry, L Hanuš - Cannabis and cannabinoid research, 2016 - liebertpub.com
Cannabidiol (CBD), the main nonpsychoactive constituent of Cannabis sativa, has shown a
wide range of therapeutically promising pharmacological effects either as a sole drug or in …

Safety and side effects of cannabidiol, a Cannabis sativa constituent

M Machado Bergamaschi… - Current drug …, 2011 - ingentaconnect.com
Cannabidiol (CBD), a major nonpsychotropic constituent of Cannabis, has multiple
pharmacological actions, including anxiolytic, antipsychotic, antiemetic and anti …

Medicinal cannabis—potential drug interactions

MA Alsherbiny, CG Li - Medicines, 2018 - mdpi.com
The endocannabinoids system (ECS) has garnered considerable interest as a potential
therapeutic target in various carcinomas and cancer-related conditions alongside …

Comprehensive review of medicinal marijuana, cannabinoids, and therapeutic implications in medicine and headache: what a long strange trip it's been…

EP Baron - Headache: The Journal of Head and Face Pain, 2015 - Wiley Online Library
Background The use of cannabis, or marijuana, for medicinal purposes is deeply rooted
though history, dating back to ancient times. It once held a prominent position in the history …

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

AA Izzo, F Borrelli, R Capasso, V Di Marzo… - Trends in …, 2009 - cell.com
Δ 9-tetrahydrocannabinol binds cannabinoid (CB 1 and CB 2) receptors, which are activated
by endogenous compounds (endocannabinoids) and are involved in a wide range of …

Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review

SM Stout, NM Cimino - Drug metabolism reviews, 2014 - Taylor & Francis
Exogenous cannabinoids are structurally and pharmacologically diverse compounds that
are widely used. The purpose of this systematic review is to summarize the data …