C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential
E Bokor, S Kun, D Goyard, M Toth, JP Praly… - Chemical …, 2017 - ACS Publications
This Review summarizes close to 500 primary publications and surveys published since
2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het) arenes. A …
2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het) arenes. A …
Geminal diheteroatomic motifs: some applications of acetals, ketals, and their sulfur and nitrogen homologues in medicinal chemistry and drug design
YJ Wu, NA Meanwell - Journal of Medicinal Chemistry, 2021 - ACS Publications
Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …
unconventional and potentially problematic scaffolding elements or pharmacophores for the …
In the search of glycoside-based molecules as antidiabetic agents
A Pałasz, D Cież, B Trzewik, K Miszczak, G Tynor… - topics in current …, 2019 - Springer
This review is an effort to summarize recent developments in synthesis of O-glycosides and
N-, C-glycosyl molecules with promising antidiabetic potential. Articles published after 2000 …
N-, C-glycosyl molecules with promising antidiabetic potential. Articles published after 2000 …
A Fries-Type Rearrangement Strategy for the Construction of Stereodefined Quaternary Pseudoanomeric Centers: An Entry into C-Naphthyl Ketosides
H Liu, M Lang, D Hazelard… - The Journal of Organic …, 2023 - ACS Publications
The stereodefined construction of quaternary pseudoanomeric centers by way of a BF3·
Et2O-catalyzed, Fries-type rearrangement of O-ketosides is described. This method provides …
Et2O-catalyzed, Fries-type rearrangement of O-ketosides is described. This method provides …
SGLT inhibitors as antidiabetic agents: a comprehensive review
RP Kshirsagar, AA Kulkarni, RS Chouthe, SK Pathan… - RSC …, 2020 - pubs.rsc.org
Diabetes is one of the most common disorders that substantially contributes to an increase
in global health burden. As a metabolic disorder, diabetes is associated with various …
in global health burden. As a metabolic disorder, diabetes is associated with various …
[HTML][HTML] A review on the medicinal chemistry of sodium glucose co-transporter 2 inhibitors (SGLT2-I): Update from 2010 to present
Diabetes mellitus (DM) is one of the leading causes of death by World Health Organization
in 2019 and is considered a significant cause of other diseases including heart attack …
in 2019 and is considered a significant cause of other diseases including heart attack …
Synthesis and biological evaluation of 6-hydroxyl C-aryl glucoside derivatives as novel sodium glucose co-transporter 2 (SGLT2) inhibitors
The sodium glucose co-transporter 2 (SGLT2) was considered as an important target for the
treatment of type 2 diabetes mellitus in recent years. This report describes the design and …
treatment of type 2 diabetes mellitus in recent years. This report describes the design and …
Recent developments in sodium-glucose co-transporter 2 (SGLT2) inhibitors as a valuable tool in the treatment of type 2 diabetes mellitus
In today's world, metabolic disorders are much dominant, and among them, diabetes is
causing the highest rate of mortality. There is no cure for diabetes, while treatment could be …
causing the highest rate of mortality. There is no cure for diabetes, while treatment could be …
Palladium‐Catalyzed Direct Benzylation of Polyfluoroarenes with Benzyl Carbonates through Selective C− H Functionalization
G Yang, X Jiang, Y Liu, N Li, G Yin… - Asian Journal of Organic …, 2016 - Wiley Online Library
A novel and efficient palladium‐catalyzed cross‐coupling benzylation reaction of
pentafluorobenzene through selective C− H functionalization has been developed. A series …
pentafluorobenzene through selective C− H functionalization has been developed. A series …