C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential

E Bokor, S Kun, D Goyard, M Toth, JP Praly… - Chemical …, 2017 - ACS Publications
This Review summarizes close to 500 primary publications and surveys published since
2000 about the syntheses and diverse bioactivities of C-glycopyranosyl (het) arenes. A …

Geminal diheteroatomic motifs: some applications of acetals, ketals, and their sulfur and nitrogen homologues in medicinal chemistry and drug design

YJ Wu, NA Meanwell - Journal of Medicinal Chemistry, 2021 - ACS Publications
Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

In the search of glycoside-based molecules as antidiabetic agents

A Pałasz, D Cież, B Trzewik, K Miszczak, G Tynor… - topics in current …, 2019 - Springer
This review is an effort to summarize recent developments in synthesis of O-glycosides and
N-, C-glycosyl molecules with promising antidiabetic potential. Articles published after 2000 …

A Fries-Type Rearrangement Strategy for the Construction of Stereodefined Quaternary Pseudoanomeric Centers: An Entry into C-Naphthyl Ketosides

H Liu, M Lang, D Hazelard… - The Journal of Organic …, 2023 - ACS Publications
The stereodefined construction of quaternary pseudoanomeric centers by way of a BF3·
Et2O-catalyzed, Fries-type rearrangement of O-ketosides is described. This method provides …

SGLT inhibitors as antidiabetic agents: a comprehensive review

RP Kshirsagar, AA Kulkarni, RS Chouthe, SK Pathan… - RSC …, 2020 - pubs.rsc.org
Diabetes is one of the most common disorders that substantially contributes to an increase
in global health burden. As a metabolic disorder, diabetes is associated with various …

[HTML][HTML] A review on the medicinal chemistry of sodium glucose co-transporter 2 inhibitors (SGLT2-I): Update from 2010 to present

J Ramani, H Shah, VK Vyas, M Sharma - European Journal of Medicinal …, 2022 - Elsevier
Diabetes mellitus (DM) is one of the leading causes of death by World Health Organization
in 2019 and is considered a significant cause of other diseases including heart attack …

Synthesis and biological evaluation of 6-hydroxyl C-aryl glucoside derivatives as novel sodium glucose co-transporter 2 (SGLT2) inhibitors

X Zhao, B Sun, H Zheng, J Liu, L Qian, X Wang… - Bioorganic & Medicinal …, 2018 - Elsevier
The sodium glucose co-transporter 2 (SGLT2) was considered as an important target for the
treatment of type 2 diabetes mellitus in recent years. This report describes the design and …

Recent developments in sodium-glucose co-transporter 2 (SGLT2) inhibitors as a valuable tool in the treatment of type 2 diabetes mellitus

S Kumar, GL Khatik, A Mittal - Mini Reviews in Medicinal …, 2020 - ingentaconnect.com
In today's world, metabolic disorders are much dominant, and among them, diabetes is
causing the highest rate of mortality. There is no cure for diabetes, while treatment could be …

Palladium‐Catalyzed Direct Benzylation of Polyfluoroarenes with Benzyl Carbonates through Selective C− H Functionalization

G Yang, X Jiang, Y Liu, N Li, G Yin… - Asian Journal of Organic …, 2016 - Wiley Online Library
A novel and efficient palladium‐catalyzed cross‐coupling benzylation reaction of
pentafluorobenzene through selective C− H functionalization has been developed. A series …