Nervous system assembly relies on a diversity of cellular processes ranging from dramatic
tissue reorganization to local, subcellular changes all driven by precise molecular programs …

Autism Spectrum Disorders (ASD) affect around 1.5% of the global population, which
manifest alterations in communication and socialization, as well as repetitive behaviors or …

CRISPR-Cas9 can be scaled up for large-scale screens in cultured cells, but CRISPR
screens in animals have been challenging because generating, validating, and keeping …

Social experiences greatly define subsequent social behavior. Lack of such experiences,
especially during critical phases of development, can severely impede the ability to behave …

Animals constantly need to judge the valence of an object in their environment: is it potential
food or a threat? The brain makes fundamental decisions on the appropriate behavioral …

Decision making is a fundamental nervous system function that ranges widely in complexity
and speed of execution. We previously established larval zebrafish as a model for …

Background The ability to filter sensory information into relevant versus irrelevant stimuli is a
fundamental, conserved property of the central nervous system and is accomplished in part …

Over the last several decades, studies in humans and animal models have successfully
identified numerous molecules required for hearing and balance. Many of these studies …

Organisms use their sensory systems to acquire information from their environment and
integrate this information to produce relevant behaviors. Nevertheless, how sensory …

Many species execute ballistic escape reactions to avoid imminent danger. Despite fast
reaction times, responses are often highly regulated, reflecting a trade-off between costly …