The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally
active intracellular domain, on force to unfold a protective domain and permit proteolysis, on …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

J. Neurochem.(2011) 117, 779–796. Abstract Regulated intramembrane proteolysis (RIP)
controls the communication between cells and the extracellular environment. RIP is …

γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral
membrane proteins within the lipid bilayer, an event preceded by shedding of most of the …

The Notch signaling pathway, which is highly conserved from sea urchins to humans, plays
an important role in cell-differentiation, survival, proliferation, stem-cell renewal, and …

Abstract Alzheimer's disease (AD), which is predicted to affect 1 in 85 persons worldwide by
2050, results in progressive loss of neuronal functions, leading to impairments in memory …

Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to
different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial …

A complex composed of presenilin (PS), nicastrin, PEN-2, and APH-1 is absolutely required
for γ-secretase activity in vivo. Evidence has emerged to suggest a role for PS as the …

The cell surface protein Trop2 is expressed on immature stem/progenitor-like cells and is
overexpressed in many epithelial cancers. However the biological function of Trop2 in tissue …