Cadmium is a toxic element to which man can be exposed at work or in the environment.
Cd's most salient toxicological property is its exceptionally long half-life in the human body …

Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic
syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance …

The liver is an important metabolic and detoxification organ and hence demands a large
amount of energy, which is mainly produced by the mitochondria. Liver tissues of patients …

Niemann–Pick type C disease (NPCD) was first described in 1914 and affects approximately
1 in 150 000 live births. It is characterized clinically by diverse symptoms affecting liver …

Mitochondrial cholesterol accumulation is a hallmark of alcoholic and non-alcoholic fatty
liver diseases and impairs the function of specific solute carriers through changes in …

The liver constantly adapts to meet energy requirements of the whole body. Despite its
remarkable adaptative capacity, prolonged exposure of liver cells to harmful environmental …

Background The liver is the central organ for cholesterol homoeostasis, and its dysfunction
might cause liver pathological alterations including hepatocellular carcinomas (HCCs). 3β …

Caffeine elicits protective effects against liver diseases, such as NASH; however, its
mechanism of action involving the pyrin domain-containing-3 (NLRP3) inflammasome …

Objective Liver fibrosis is part of the non-alcoholic fatty liver disease (NAFLD) spectrum,
which currently has no approved pharmacological treatment. In this study, we investigated …