Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications

P Tan, H Fu, X Ma - Nano Today, 2021 - Elsevier
Antibiotic resistance caused by antibiotic abuse, especially the emergence of multi-drug
resistant bacteria, poses a serious threat to human health, and makes it imperative to find …

Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects

RK Thapa, DB Diep, HH Tønnesen - Acta biomaterialia, 2020 - Elsevier
Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their potent
antibacterial and wound healing properties. Bare AMPs have limited activity following topical …

Advances of peptides for antibacterial applications

Y Yan, Y Li, Z Zhang, X Wang, Y Niu, S Zhang… - Colloids and Surfaces B …, 2021 - Elsevier
In the past few decades, peptide antibacterial products with unique antibacterial
mechanisms have attracted widespread interest. They can effectively reduce the probability …

Synthetic extracellular matrices with function-encoding peptides

C Ligorio, A Mata - Nature reviews bioengineering, 2023 - nature.com
The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

Y Wang, J Zhan, J Huang, X Wang… - Interdisciplinary …, 2023 - Wiley Online Library
Dynamic‐responsive self‐assembly is the process of ordered supramolecular structure
formation or reversible decomposition from building blocks. This process is driven by non …

Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities

P Cardoso, H Glossop, TG Meikle, A Aburto-Medina… - Biophysical …, 2021 - Springer
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Nanostructured antimicrobial peptides: The last push towards clinics

JV Carratalá, N Serna, A Villaverde, E Vázquez… - Biotechnology …, 2020 - Elsevier
Peptide drugs hold great potential for the treatment of infectious diseases due to their
unconventional mechanisms of action, biocompatibility, biodegradability and ease of …

Self‐assembled peptide‐based nanodrugs: molecular design, synthesis, functionalization, and targeted tumor bioimaging and biotherapy

X Luan, H Kong, P He, G Yang, D Zhu, L Guo, G Wei - Small, 2023 - Wiley Online Library
Functional nanomaterials as nanodrugs based on the self‐assembly of inorganics,
polymers, and biomolecules have showed wide applications in biomedicine and tissue …

Antibiotic delivery strategies to treat skin infections when innate antimicrobial defense fails

R Smith, J Russo, J Fiegel, N Brogden - Antibiotics, 2020 - mdpi.com
The epidermal skin barrier protects the body from a host of daily challenges, providing
protection against mechanical insults and the absorption of chemicals and xenobiotics. In …

Physicochemical Features and Peculiarities of Interaction of AMP with the Membrane

M Pirtskhalava, B Vishnepolsky, M Grigolava… - Pharmaceuticals, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are anti-infectives that have the potential to be used as a
novel and untapped class of biotherapeutics. Modes of action of antimicrobial peptides …