WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and
tissue homeostasis. Misregulation of intracellular signal transduction can lead to …

Cardiovascular disease is a leading cause of death worldwide. The limited capability of
heart tissue to regenerate has prompted methodological developments for creating de novo …

Understanding heart development on a molecular level is a prerequisite for uncovering the
causes of congenital heart diseases. Therapeutic approaches that try to enhance cardiac …

The generation and expansion of diverse cardiovascular cell lineages is a critical step
during human cardiogenesis, with major implications for congenital heart disease …

Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the
animal life by controlling the genetic programs of embryonic development and adult …

Cell fate decisions of pluripotent embryonic stem (ES) cells are dictated by activation and
repression of lineage-specific genes. Numerous signaling and transcriptional networks …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from …

The heart is the first organ formed during mammalian development. A properly sized and
functional heart is vital throughout the entire lifespan. Loss of cardiomyocytes because of …