Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Reactions that occur under physiological conditions find diverse uses in the chemical and
biological sciences. However, the limitations that biological systems place on chemical …

Over the past 16 years, genetic code expansion and reprogramming in living organisms has
been transformed by advances that leverage the unique properties of pyrrolysyl-tRNA …

Labeling of a protein with a specific dye or tag at defined positions is a critical step in tracing
the subtle behavior of the protein and assessing its cellular function. Over the last decade …

The DA structured small-molecule-based resistive random-access memory (ReRAM) device
has been well-researched in the last decade, and the switching mechanism was mainly …

Site-specific introduction of bioorthogonal handles into biomolecules provides powerful tools
for studying and manipulating the structures and functions of proteins. Recent advances in …

Conformationally strained trans-cyclooctenes (TCOs) engage in bioorthogonal reactions
with tetrazines with second order rate constants that can exceed 10 6 M− 1 s− 1. The goal of …

Chemically modified proteins have diverse applications; however, conventional chemo‐
selective methods often yield heterogeneously labeled products. To address this limitation …

An 18F-labeled trans-5-oxocene (oxoTCO) that is used to construct a PET probe for
neurotensin receptor (NTR) imaging through tetrazine ligation is described here. PET probe …

A facile method to synthesize pyridazines from 1, 2, 4, 5-tetrazines and alkynes is disclosed.
The reaction was significantly facilitated by 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol. The wide …