Epilepsy is among the most dynamic disorders in neurology. A canonical view holds that
seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans …

The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes
sequential behavioral and electrographic changes that can be divided into 3 distinct …

Molina‐Carballo A, Muñoz‐Hoyos A, Reiter RJ, Sánchez‐Forte M, Moreno‐Madrid F, Rufo‐
Campos M, Molina‐Font JA, Acuña‐Castroviejo D. Utility of high doses of melatonin as …

The pineal gland classically has been considered as a vestigial and mystic organ. In the last
decades, and with the incorporation of new methodologic procedures, it could be proved …

Knowledge on the interaction between circadian rhythm and human epilepsy is relatively
poor, although if it exists, this interaction may be of value for better knowledge of …

The aim of the study was to compare sleep patterns in children with epilepsy with those of
their non-epileptic siblings and to determine which epilepsy-specific factors predict greater …

Time of occurrence of 188 first febrile seizures (FS) was recorded, both by four 6-hour
periods and by hourly intervals. The frequency of events was significantly (P<. 001) …

Abstract Melatonin (N-acetyl-5-methoxytryptamine, aMT) is an indoleamine produced by
several organs and tissues including the pineal gland. Melatonin (aMT) modulates the …

Approximately one-third of patients with epilepsy continue to have seizures despite
antiepileptic therapy. Many seizures occur in diurnal, sleep/wake, circadian, or even monthly …

Melatonin (50 mg/kg; 60 min before the test) significantly raised the electroconvulsive
threshold in mice. The protective action of melatonin (50 mg/kg) in the electroconvulsive …