The potassium-sparing diuretic amiloride has proven to be a useful pharmacological tool for
elucidating the molecular basis and physiological regulation of facilitated sodium entry in …

Transporting epithelia posed formidable conundrums right from the moment that Du Bois
Raymond discovered their asymmetric behavior, a century and a half ago. It took a century …

The established mouse cell line NIH 3T3 has been used with considerable success over the
past three years as the basis of an in vitro transformation assay for demonstrating the …

The mechanisms by which growth factors stimulate metabolism and cell proliferation are
largely unknown. Recent evidence suggests that mitogens rapidly activate a Na+/H+ …

Numerous previous studies have proposed a role for angiotensin II (AII) in the renal
regulation of salt balance. At least one nephron site, the proximal convoluted segment, has …

Primary cultures of rabbit-kidney epithelial cells derived from purified proximal tubules were
maintained without fibroblast overgrowth in a hormone-supplemented serum-free medium …

An Na+/H+ antiporter is a carrier that catalyzes the exchange of Na+ and H ק, ie, trans-
Abbreviations: drill+, electrochemical gradient of H+; A/iNa+, electrochemical gradient of …

Properties of some of the best characterized neutral amino acid transport systems in tissue
cells are summarized in Table 1. The subcellular localizations and regulatory characteristics …

Primary cultures of baby mouse kidney epithelial cells can grow without fibroblast
overgrowth in a hormone‐supplemented serum‐free medium (Medium K‐1) designed for an …

Human fibroblasts that have been serum deprived for 4 hours have a digitoxin‐insensitive
Na influx of 9.5±1.0 (n= 4) μmol/g prot/min which is not significantly different from the influx of …