Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

Bile acids are best known as detergents involved in the digestion of lipids. In addition, new
data in the last decade have shown that bile acids also function as gut hormones capable of …

Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we
demonstrate that fibroblast growth factor 15 (FGF15) signals from intestine to liver to repress …

Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on
target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co …

The fibroblast growth factor (FGF) 19 subfamily of ligands, FGF19, FGF21, and FGF23,
function as hormones that regulate bile acid, fatty acid, glucose, and phosphate metabolism …

FGF signaling plays a ubiquitous role in human biology as a regulator of embryonic
development, homeostasis and regenerative processes. In addition, aberrant FGF signaling …

Unique among fibroblast growth factors (FGFs), FGF19,-21, and-23 act in an endocrine
fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis …

Fibroblast growth factors (FGFs) signal in a paracrine or endocrine fashion to mediate a
myriad of biological activities, ranging from issuing developmental cues, maintaining tissue …