Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …

The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

A variety of genetically encoded reporters use changes in fluorescence (or Förster)
resonance energy transfer (FRET) to report on biochemical processes in living cells. The …

ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of
cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent …

Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …

Multiple sclerosis (MS) is an inflammatory disorder causing central nervous system (CNS)
demyelination and axonal injury. Although its etiology remains elusive, several lines of …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

Eph receptors constitute the largest family of tyrosine kinase receptors and, together with
their plasma-membrane-bound ephrin ligands, have many important functions during …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors
seem to modulate RhoA activity by binding to a receptor complex comprising a ligand …