Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this
compound is naturally produced in many plant and animal food sources, as well as in cells …

All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

The human gut is a composite anaerobic environment with a large, diverse and dynamic
enteric microbiota, represented by more than 100 trillion microorganisms, including at least …

Palmitoylethanolamide (PEA, N-hexadecanoylethanolamide) is an endogenous compound
belonging to the family of N-acylethanolamines. PEA has anti-inflammatory and analgesic …

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …

Glia and microglia in particular elaborate pro‐inflammatory molecules that play key roles in
central nervous system (CNS) disorders from neuropathic pain and epilepsy to …

Parkinson's disease (PD) is a progressive, disabling neurodegenerative disorder. It has
been shown Toll like receptor (TLR) 4-deficient mice protect against MPTP toxicity …

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors,
the primary molecular targets responsible for the pharmacological effects of the Δ9 …